When should I inject sermorelin?

Inject sermorelin once at night, 60-90 minutes after your last meal and 30 minutes before sleep. This timing matches your body's natural growth hormone pulse, which happens during deep sleep. Eating raises insulin and blood sugar, both of which blunt growth hormone release - so dosing on a relatively empty stomach is important. Sermorelin works fast and clears fast (half-life is about 11-20 minutes), so it does its job in one short window each night.

• Sermorelin's half-life is about 11-20 minutes - it acts in a single short pulse
• Largest natural GH pulses happen in the first hour or two of deep sleep
• High insulin and high blood sugar both blunt growth hormone release
• Most clinical protocols dose 100-300 mcg once nightly
• Sermorelin was approved in the US under the brand Geref in 1997 for pediatric growth hormone deficiency; the brand was discontinued in 2008 for business reasons, not safety

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