When should I take PT-141 and how often is too often?

Take PT-141 at least 45 minutes before sexual activity. The Vyleesi prescribing label allows up to one dose every 24 hours and no more than 8 doses per month. Most people in the trials used it 2-3 times per month, never more than once a week. Dosing more often increases your risk of skin darkening (focal hyperpigmentation) and longer stretches of raised blood pressure. PT-141 is on-demand, not a daily peptide.

• Vyleesi label: 1.75 mg subcutaneous, max 1 dose/24 hours, max 8 doses/month
• Median use in the phase 3 trials was 10 injections over 24 weeks - lower than many people expect
• Optimal timing window has not been fully characterized; 45 min is the labeled minimum
• Effect duration is variable; patients are encouraged to learn their own response curve
• Compounded versions follow the same on-demand pattern, even if the dose is different

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