PRTCL.
What to Expect

What should I expect from my first PT-141 dose?

Updated 2026-05-04

Three things show up most in trials: facial flushing in roughly 1 in 5 people, headache in roughly 2 in 5, and nausea in roughly 1 in 4. Reported effects tend to start within 30 to 60 minutes and ease over the next few hours. The dose, the timing, and whether it fits your health history are decisions for you and your provider, not numbers the app sets for you. If you get the green light, the reconstitution calculator can turn the dose you and your provider land on into syringe units. Bring any heart or blood pressure history to that conversation, since the prescribing label carries a boxed warning around uncontrolled hypertension.

IfIf your face flushes or feels warm
Thenthen know flushing is one of the more commonly reported effects and usually eases within a couple of hours; check with your provider about what is normal for you
IfIf you get a strong headache
Thenthen headache is a reported effect worth flagging to your provider, who can advise on next steps
IfIf nausea hits hard
Thenthen nausea is the effect people report most in trials; your provider can walk you through ways to manage it
IfIf you have uncontrolled high blood pressure
Thenthen talk with your provider before using it, since the prescribing label carries a boxed warning around uncontrolled hypertension
Key facts
  • Bremelanotide (PT-141) is approved in the US for premenopausal women with HSDD under the brand Vyleesi
  • Common side effects in the RECONNECT trials: nausea (~40%), flushing (~20%), headache (~11%), injection site reactions
  • Onset 30-60 minutes after subQ injection, peak 1-2 hours, total duration 2-4 hours
  • Transient blood pressure increase of 6 mmHg systolic / 3 mmHg diastolic is documented in the prescribing label
  • Boxed warning on the prescribing label restricts use in uncontrolled hypertension and known cardiovascular disease
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