How long should I be off a GLP-1 before trying to get pregnant?

The published prescribing labels say stop semaglutide at least 2 months before trying to conceive, and stop tirzepatide at least 1 month before. The longer washout for semaglutide is because it has a longer half-life. Animal studies showed harm to the developing fetus at exposures near human doses, and there is not enough human data to call it safe in pregnancy. If you're already pregnant, stop your weekly injection and call your OB.

• Semaglutide half-life is about 1 week, so it takes about 5 weeks to clear; the label uses a 2-month conservative washout
• Tirzepatide half-life is about 5 days; the label uses a 1-month washout
• Animal studies of both showed reduced fetal growth and skeletal abnormalities at clinical exposures
• There is no controlled human pregnancy data confirming safety for either drug
• Tirzepatide also reduces oral contraceptive effectiveness, so an unplanned pregnancy is more likely if you only use the pill

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