Will I lose my hair on semaglutide or tirzepatide?

Some people do. It's not the drug attacking your hair - it's your body reacting to rapid weight loss. Doctors call this telogen effluvium. Hair shedding typically starts 2 to 3 months after major weight loss and lasts 3 to 6 months. It's almost always temporary. Hair regrows in about 95% of acute cases. In the trials: Wegovy 3% vs 1% placebo; Zepbound 5% vs 1% placebo, with women hit harder (7.1% vs 0.5% in men).

• Telogen effluvium mechanism: rapid weight loss is a physiological stressor that pushes up to 70% of hair follicles from anagen (growth) to telogen (resting/shedding) at the same time
• Onset: typically 2 to 3 months after a significant weight loss event
• Duration: shedding period 3 to 6 months; hair regrows in about 95% of acute cases
• Not unique to GLP-1s - the same effect occurs after bariatric surgery
• Zepbound label data: roughly 4 to 5% of trial participants reported hair loss vs 1% on placebo; women 7.1% vs men 0.5%; and no patients discontinued because of it

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