How do I cycle GHK-Cu on and off?
Most GHK-Cu protocols run 30-60 days on, then 30-60 days off. The off period exists to let copper levels normalize, since you are adding copper to your body every time you inject. Some protocols also use 5 days on, 2 days off inside each cycle to keep the daily exposure lower. There is no human trial that proves this cycling pattern is needed; it is precaution borrowed from how the body handles copper, not a safety rule. If you are short on time, even a 4 week on / 4 week off cadence is reasonable.
- The cycle exists for copper load management, not for receptor desensitization
- Daily dietary copper intake from food is typically 1-2 mg; injecting 1-2 mg roughly doubles your daily copper exposure
- Total body copper is about 80-100 mg, with the liver as the primary regulator
- Some protocols mix GHK-Cu with non-copper peptides during the off cycle (e.g. BPC-157, TB-500) for continued recovery
- No peer-reviewed human trial has tested optimal injectable GHK-Cu cycling; cycling guidance comes from compounding pharmacy protocols
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